Science Journal of Medicine and Clinical Trials
April 2013,Volume 2013, ISSN: 2276-7487
© Author(s) 2013. This work is distributed under the Creative Commons Attribution 3.0 License.
Research Article
Effect of Long Term Administration of Solanum Nigrum Extracts in Female Swiss White Mice Infected with Trypanosoma Brucei Rhodesiense
Serem, Erick Kibichiy1. Ngure, Raphael M2. Chome, Jonathan1. Korir, Scolastica C1. Mdachi, Raymond E.1 and Mburu, Jane N.4
1Department of Biological Sciences, Egerton University, P. O Box 536-20115 Egerton.
2Biochemistry and Molecular Biology Department, Egerton University. P. O Box 536-20115 Egerton.
3Kenya Agricultural Research Institute- Trypanosomosis Research Centre, Pharmacology and Chemotherapy Division. P.O Box 362- 00902, Kikuyu.
4Animal Sciences Department, Egerton University, P. O Box 536-20115 Egerton.
Accepted 21 April, 2013; Available Online 27 April, 2013
doi: 10.7237/sjmct/290
Abstract:
Trypanosomosis progression and prognosis in female mice varies on the concentrations of the drug used due to the differences in which metabolites are accumulated or excreted from their bodies. Female Swiss white mice were infected with Trypanosoma brucei rhodesiense and treated with different concentrations of Solanum nigrum extract (SNE). The results indicated that mice treated with 10g/L and 6.7g/L of SNE had significantly lower survival time probably due to the accumulation of metabolites to toxic levels while mice treated with 3.3g/L had a longer survival time due to the beneficial effect of the extract. The mice treated with 3.3g/L SNE also had lower parasitaemia levels and significantly higher PCV, body weights and albumin levels compared to the infected mice treated with dexamethasone and higher concentrations of SNE. In summary, lower concentrations of SNE should be used in the treatment of female mice to avoid accumulated SNE metabolites to toxic levels.
Keyword:Survival time, Mice, Females, Toxicity, Metabolite accumulation, Chronic therapy