Science Journal of Medicine and Clinical Trials
June 2013,Volume 2013, ISSN: 2276-7487
© Author(s) 2013. This work is distributed under the Creative Commons Attribution 3.0 License.
Research Article
Assessment Of Different Strengths Of Levofloxacin In The Treatment Of Acute Bacterial Sinusitis
Dr. Rameez Shah1, Dr. Md. Bahauddin2, Dr. Md. Rafiqul Islam3, Dr. Md. Mahmudur Rahman4, Dr. Md. Shahriar Islam5 and Dr. Mostafa Kamal Arefin6
1,2,4,5,6Dept of ENT & Head Neck Surgery, Dhaka Medical College Hospital, Dhaka Bangladesh.
3Diabetic Association Medical College Hospital, Faridpur, Bangladesh.
Accepted 24 June, 2013; Available Online 30 June, 2013
doi: 10.7237/sjmct/252
Abstract:
Aim: Assessment of different strengths of levofloxacin in the treatment of
acute bacterial sinusitis.
Method: A total of 580 subjects were included in the study trial comparing
levofloxacin 750 mg for 5 days vs levofloxacin 500 mg for 10 days at Dhaka
Medical College, Dhaka, Bangladesh from January 2011 to December 2012.
Results: Sinus fluid samples were obtained by antral puncture (59.2%) or
by sinus endoscopy (40.8%). Among microbiologically evaluable patients,
91.4% of patients receiving levofloxacin 750 mg achieved clinical success vs
88.6% of patients receiving levofloxacin 500 mg (95% CI -10.0, 4.2). Clinical
success rates by pathogen were above 90% in both treatment groups for
the 3 typical pathogens of acute sinusitis: Streptococcus pneumoniae,
Haemophilus influenzae, and Moraxella catarrhalis. The safety profile of the
2 dosage strengths was similar.
Conclusion: Levofloxacin 750 mg for 5 days is not inferior to levofloxacin
500 mg for 10 days.
Keyword:waist circumference, nutritional intervention, diet, visceral fat, cardio-metabolic risk, metabolic syndrome