Science Journal of Medicine and Clinical Trials

December 2013,Volume 2013, ISSN: 2276-7487

Author(s) 2013. This work is distributed under the Creative Commons Attribution 3.0 License.

Research Article

 

Comparison of the Efficacy of Midazolam Vs. Ondansetron in Preventing Post Operative Nausea and Vomiting in Gynecologic Laparoscopic Surgeries:Double-blinded Randomized Clinical Trial Study

Leili Hafizi1, Mahsa Kiafar2, Arash peyvandi3, Alireza Sepehri Shamloo4, Samira Andalibizadeh5, Masoume Nouri6,
Nahid Zirak7*

1Assistant professor of Obstetrics and Gynecology, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
2Obstetrician and Gynecologist, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
3Assistant professor of Anesthesiology, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
4Student Research Committee, School of medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
5Medical student, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
6Medical student, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
7*Associated professor of Anesthesiology, Imam Reza Hospital, Faculty of Medicine, Cardiac Anesthesia Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, and Mashhad, Iran.

Accepted 1st November, 2013; Available Online 16 December,2013

doi: 10.7237/sjmct/178

Abstract:

Introduction:Post operative nausea and vomiting (PONV) can be seen more commonly in women and especially in gynecologic and laparoscopic surgeries. One of the drugs suggested as a pre-treatment is midazolam. This study investigated the effect of midazolam in reducing post operative nausea and vomiting in comparison with ondansetron.
Method:In this double blind randomized clinical trial 80 patients who were met inclusion and exclusion criteria were randomly allocated in two equal groups of 40, each receiving either midazolam (received 15 mg/kg during induction of anesthesia) or ondansetron (4 mg IV, 15 min before extubation) . Information regarding occurrence of nausea and vomiting in 0, 2, 6 and 24hours after extubation were recorded in a questionnaire.
Results:The nausea score in the recovery, 2, 6 and 24 hours after extubation, was not significantly different between the two groups.Frequency of vomiting was higher in midazolam group than ondansetron group at 2 and 6 hours post recovery, but was the same at 24 hours.
Conclusion:Although midazolam premedication was not more effective than ondansetron in reducing postoperative nausea and vomiting but in many intervals the effect was similar to ondansetron; in which justifies its use with other anti-nausea medications.

Keyword: ondansetron, nausea, vomiting, laparoscopic, gynecologic, midazolam

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