Science Journal of Medicine and Clinical Trials
April 2014,Volume 2014, ISSN: 2276-7487
© Author(s) 2014. This work is distributed under the Creative Commons Attribution 3.0 License.
Activated Protein C Resistance in Adult Sudanese Patients diagnosed with Deep Vein Thrombosis
Safia Khalil Ali Taha1 and Anwaar Ahmed Yousif Kordofani2
1Medical Laboratory Science - Haematology and immunohaematology . Omdurman Islamic University
2MBBS ,DCP, FRCPath , U K
Accepted 8 April, 2014; Available Online 3 April,2014
Resistance to activated protein C in both its acquired and hereditary forms is a known risk factor for the development of venous thromboembolic disorders. It is reported to be found in 3% to 5% of the general population and it is responsible for 20% to 50% of thrombosis in patients. The prevalence of Activated Protein C Resistance (APCR ) is estimated to be high in Caucasians, while Asians and Africans are thought to have a low incidence . Among Arabs, there is a difference in the prevalence of APCR in different sub-nationalities. The prevalence in Sudanese subjects has not so far been determined in spite of the high incidence of DVT, so this cross- sectional study was carried out to determine the prevalence of activated protein C resistance among adult Sudanese patients with Deep vein thrombosis (DVT). One hundred and thirty eight adult patients admitted to Khartoum State hospitals who were diagnosed as having DVT were included in this study. APCR ratios were determined for them using a semi automated coagulometer. (Thrombotimer 4 channel coagulometer). Prevalence of APCR in the studied group was found to be (33.3%). Inherited APCR seemed to be more prevalent among those patients than the the acquired one. Family history, age, and some associated clinical conditions like postnatal period, pregnancy and cancer were significantly associated with APCR.
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